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Synthetic Cannabinoids

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Synthetic Cannabinoids

Editor's note: This entry is incomplete, and is undergoing revision. The CannaScholar editor‑in‑chief will release the completed version in the coming months; at which time this notice will be removed. In the meantime, we present the following article; which serves as an introductory overview of the topic. We are grateful for your understanding. As always, you are welcome to reach out to a certified Hempist with any questions.


Synthetic (adjective): Relating to a substance produced by chemical synthesis, designed to mimic a natural product.

The Risks of Synthetic Cannabinoids

The pursuit of a potent high may lure unsuspecting users to the realm of synthetic cannabinoids, but the hidden dangers are considerable. The cannabis market, sadly, has many brands that prioritize profit over consumer safety; ignoring the serious health risks of counterfeit cannabinoids. Science has shown that synthetic substitutes predictably fall short of their natural counterparts, and frequently cause adverse reactions.

A notable culprit amidst these fake cannabinoids is THC-O, a substance touted to be tenfold more potent than its natural counterpart, Delta-9 THC. Despite its popularity, THC-O is synthetic, not occurring in nature, and is entirely unstudied. While the effects of natural cannabinoids like THCa, Delta-9 THC, and Delta-8 THC are well-researched and documented, THC-O remains a mystery.


THC-O is a purely artificial cannabinoid. Unlike the familiar cannabis-derived cannabinoids – CBD, CBG, THC, CBC, and CBN – THC-O is concocted in laboratories.

To produce THC-O, a compound named acetic anhydride – typically used for manufacturing plastics and pharmaceuticals – is chemically fused with Delta-8 or Delta-9 THC. This process yields a THC-O molecule; which should give one pause, given its dubious unnatural origins.

Currently, the scientific and medical communities are in the dark concerning THC-O’s interaction with the human body, leaving safety and health effects relegated to the unknown. Yet, THC-O products are widely available, even at gas stations; which begs caution, and underscores the need for awareness.


Spice (or K2) refers to a collection of synthetic cannabinoid products that can have unpredictable and dangerous effects. These lab-created compounds bind to the same receptors as THC (the primary psychoactive component in cannabis), but with greater affinity.

Reported side effects range from extreme anxiety and paranoia, to kidney damage and seizures. Because they are not regulated, and their composition often varies, users have no certainty about what they’re actually consuming. The risks associated with these products make them highly advisable to avoid.

Our stance

Our commitment to health and quality at our company is absolute. After conducting thorough research, we educate our customers to avoid the use of any synthetic cannabinoids. We have always steered clear of such compounds, and will continue to do so.

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Disclaimer: The content presented by Cloud Hempistry, LLC, here on the CannaScholar blog, or elsewhere, is provided solely for educational purposes only; and is not intended to constitute medical advice. You should consult your physician prior to using cannabis to determine if it is appropriate for your particular needs and goals.

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